Uveitis Associated with Systemic Diseases: Clinical Features, Diagnosis and Treatment

Uveitis is a frequently seen entity with systemic immune mediator related diseases. Among these diseases, Behçet’s disease, sarcoidosis, spondylarthropathies and juvenile idiopathic arthritis are relatively common. In this group of patients, uveitis may result in visual loss. Additionally, eye involvement may also be the presenting sign of these life-threatening systemic diseases. Therefore, early diagnosis and proper treatment of these diseases are important. Corticosteroids are the first choice of treatment in this group of patients. However, their use is limited due to potential side effects in the long-term. In recent years, increasing number of immunomodulatory drugs and biological agents are being used more effectively to reduce complications related to these diseases. In this review, clinical features, diagnostic dilemma and treatment options of uveitis associated with non-infectious systemic diseases were evaluated.