Pathogenesis in Wet-Form (Neovascular) Age-Related Macular Degeneration

The understanding of the pathogenesis of the development of choroidal neovascularization (CNV) in age related macular degeneration (AMD) continues to evolve. Epidemiological, histopathological and biochemical evidence indicates that neovascular AMD is associated with oxidative damage, lipofuscin accumulation, chronic inflammation, and mutation in complement system. Molecular targets have been identified that serve as the basis for developing new, better treatments for neovascular AMD.